Accessible only by boat, at the confluence of the Colombian Amazon and Orinoco, La Manigua Lodge is a wonderful base for Caño Cristales, the remote river that blazes in reds, yellows, and greens during colour season. La Macarena is still finding its feet as a tourist destination, which gives a stay here a frontier quality that more established regions have long since lost. Luxury here is redefined as tranquillity and access rather than thread counts. Large, elevated, screened cabins put you genuinely inside the jungle, guided by a community of over 200 local families with a stake in getting it right.